منابع مشابه
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Altered function of the ubiquitin pathway has been implicated in the etiology of neurodegeneration. For example, gracile axonal dystrophy (gad) mutant mice, which harbor a deletion within the gene encoding ubiquitin C-terminal hydrolase L1 (Uch-L1), display sensory ataxia followed by posterior paralysis and lethality. We previously showed that mice homozygous for a targeted deletion of the rela...
متن کاملThe binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3.
The ubiquitin fold is a versatile and widely used targeting signal that is added post-translationally to a variety of proteins. Covalent attachment of one or more ubiquitin domains results in localization of the target protein to the proteasome, the nucleus, the cytoskeleton or the endocytotic machinery. Recognition of the ubiquitin domain by a variety of enzymes and receptors is vital to the t...
متن کاملA "threepenny" CPR manikin.
Manikins are essential in teaching and practicing CPR. Industry as provided them in different degrees of complexity. Costs are irectly proportional to sophistication and in some cases it might e a limiting factor especially among poor people. Training programs in emergencies have been developed for umble populations, and have included the use of a CPR dummy ade with simple materials – in compar...
متن کاملHRTF measurement on KEMAR manikin
Presenting sounds to humans in virtual environments requires convolving the free field signals with a head related transfer function (HRTF), which is a frequency response describing the filtering effects of the pinna, head and torso of a human. Sets of HRTFs are usually measured on the dummy head or human subjects at different directions in an anechoic room. This paper describes the details of ...
متن کاملDesign and Development of the ASPECT Manikin
The primary objective of the ASPECT (Automotive Seat and Package Evaluation and Comparison Tools) program was to develop a new generation of the SAE J826 Hpoint manikin. The new ASPECT manikin builds on the long-term success of the H-point manikin while adding new measurement capability and improved ease of use. The ASPECT manikin features an articulated torso linkage to measure lumbar support ...
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ژورنال
عنوان ژورنال: African Journal of Urology
سال: 2014
ISSN: 1110-5704
DOI: 10.1016/j.afju.2014.03.016